Asian Journal of Pharmacy and Technology

G. Kalyani ¹, P. Bhuvaneswari ¹, B. Hemalatha ¹, K. Padmalatha ²

Affiliations
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN

Abstract

Solubility is one of the key parameters to attain desired concentration of drug in systemic circulation to show pharmacological response. Various methods are engaged to augment the aqueous solubility of poorly water-soluble drugs and hydrotropic solubilisation is one of them. Hydrotropy is defined as a solubilization process whereby addition of a large amount of second solutes results in an increase in the aqueous solubility of another solute and chemicals which are used in the hydrotropy are called hydrotropes like sodium benzoate, sodium citrate, urea, niacinamide etc. Based on advantages like the high selectivity, independent of pH and cheap, easy availability makes this technique more prevailing than other solubilisation methods. Mixed hydrotropy is a solubilisation technique to augment the water solubility of poorly water soluble drugs by the way of different ratio of blends of hydrotropic agents which gives synergistic augmentation effect. The purpose of this review article is to illustrate the need for solubility, hydrotropic solubilisation, mechanism of action of hydrotrope, classification of hydrotropes, advantages and mixed hydrotropic technique of solubilisation for improving the solubility which in turn helps to attain absorption and improved bioavailability.

Keywords

Hydrotropy, Hydrotropes, Solubility, Mixed Hydrotropy, Solubilisation

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K. Naga Durga ¹, P. Bhuvaneswari ¹, B. Hemalatha ¹, K. Padmalatha ²

Affiliations
1 Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN
2 Department of Pharmacology, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, IN

Abstract

Nowadays about 74% of drugs are taken orally and are found not to be as effective as required. To improve such characters transdermal drug delivery system was emerged. Drug delivery through the skin to attain a systemic effect of a drug is commonly known as transdermal drug delivery and differs from traditional topical drug delivery. Transdermal drug delivery systems (TDDS) are dosage forms involves drug transport to viable epidermal and or dermal tissues of the skin for local therapeutic effect while a very major fraction of drug is transported into the systemic blood circulation. The adhesive of the transdermal drug delivery system is critical to the safety, efficacy and quality of the product. Topical administration of therapeutic agents offers many advantages over conventional oral and invasive methods of drug delivery. Several important advantages of transdermal drug delivery are limitation of hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug. This review article provides an overview of advantages and disadvantages, factors affecting transdermal drug delivery, components and types of transdermal drug delivery, methods of preparation and methods of evaluation.

Keywords

TDDS, Topical Drug Delivery, Systemic Blood Circulation, Skin

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